The photocatalytic degradation of betamethasone sodium phosphate was investigated in aqueoussuspensions of zinc oxide nanoparticular with diameter size 20 nm under a variety of conditions.Different parameters such as irradiation time, the amount catalyst (0.12-0.8 g LH), initialconcentration of drug (10-50 mgLjand initial pH values (ranging from 3 to II) were investigatedin the presence of vari...

BACKGROUND Central nervous system injuries after transforaminal epidural steroid injections have been ascribed to occlusion of the blood vessels supplying the spinal cord and brain by the particulate steroid. METHODS The authors compared the sizes of the particles of the steroids methylprednisolone acetate, triamcinolone acetonide, dexamethasone sodium phosphate, betamethasone sodium phosphat...

the photocatalytic degradation of betamethasone sodium phosphate was investigated in aqueoussuspensions of zinc oxide nanoparticular with diameter size 20 nm under a variety of conditions.different parameters such as irradiation time, the amount catalyst (0.12-0.8 g lh), initialconcentration of drug (10-50 mgljand initial ph values (ranging from 3 to ii) were investigatedin the presence of vari...

The intended purpose of this work is to develop and validate a dissolution test for betamethasone acetate and betamethasone sodium phosphate injectable suspension using a reverse-phase liquid chromatographic method. After testing sink conditions, dissolution medium and stability of the drug, the best conditions were: flow through cell of diameter 22.6 mm, 2.0 ml per minutes flow rate for 120 mi...

OBJECTIVE To evaluate at which pH level various local anesthetics precipitate, and to confirm which combination of corticosteroid and local anesthetic crystallizes. METHODS Each of ropivacaine-HCl, bupivacaine-HCl, and lidocaine-HCl was mixed with 4 different concentrations of NaOH solutions. Also, each of the three local anesthetics was mixed with the same volume of 3 corticosteroid solution...

BACKGROUND Betamethasone is used for its antiinflammatory and immunosuppressive effects in disorders of many organ systems. However, the pharmacokinetic properties of betamethasone in plasma after intramuscular injection of betamethasone sodium phosphate and betamethasone acetate dual-acting suspension need further investigation. OBJECTIVES The main aim of this study was to determine the phar...

Intranasal betamethasone sodium phosphate drops (Betnesol) are frequently used to relieve nasal congestion due to polyposis. We report a case of significant hypothalamic-pituitary-adrenal suppression secondary to the long-term use of intranasal betamethasone drops. This case emphasizes that the topical application of potent corticosteroids may produce systemic effects.

BACKGROUND Epidural injection of corticosteroids is a commonly used treatment for radicular pain. However, the benefits are often short lived, and repeated injections are often limited secondary to concerns of side effects from cumulative steroid doses. In addition, rare, catastrophic complications, including brain and spinal cord embolic infarcts have been attributed to particulate steroid inj...

Popliteal or otherwise called Baker’s cyst represents a fluid distension of the gastrocnemiosemimembranosus bursa and is usually incidentally found on imaging studies. However, the clinical manifestation of symptomatic Baker’s cyst is similar to thrombophlebitis hence the term pseudothrombophlebitis syndrome. We add to the literature a case of a partially ruptured popliteal cyst in which locall...

This study was performed to investigate the effects of adrenocorticoid steroids, Prednisolone sodium hemisuccinate, Dexamethasone, and Betamethasone disodium phosphate, on the wound healing of permanent pacemaker implantation, especially on the :findings of redness and local hemorrhage. It was found that prednisolone sodium hemisuccinate and betamethasone disodium phosphate had a remarkable pro...